We all are different. Some are tall some short. Some have blue eyes and some have brown. We also know the way we metabolize drugs can be different and this could be a big deal.
For instance according to a recent CDC study ,when looking at deaths involving other pharmaceuticals, opioids were often also present in:
• 77.2% of benzodiazepine deaths
• 65.5% of anti-epileptic and anti-parkinsonism drugs
• 58% of antipsychotic and neuroleptic drugs
• 57.6% of antidepressants
• 56.5% other analgesics, anti-pyretics, and anti-rheumatics
• 54.2% of other psychotropic drugs
More data is coming out showing that drug overdose deaths don’t always result from someone downing an entire bottle of their prescription medications like movies often portray. More often these deaths occur by mixing medications that either potentiate one another or compete for similar metabolic pathways. A good analogy might be something we all have experienced at a crowded subway platform where many people are trying to move on using the same broken turnstile. Disorder can result.
Most of the drug classes listed above are metabolized by the cytochrome system of enzymes( “the turnstile”). Pharmacogeneomic data now proves that mutations can affect efficiency. At Balcones Pain Consultants we look for these differences through our genetic testing so that if a cocktail is required it’s carefully crafted.